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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2009 1
2011 1
2012 3
2013 2
2014 4
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2017 7
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2019 19
2020 23
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2022 11
2023 10
2024 7

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113 results

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H. pylori-induced NF-kappaB-PIEZO1-YAP1-CTGF axis drives gastric cancer progression and cancer-associated fibroblast-mediated tumour microenvironment remodelling.
Chen B, Liu X, Yu P, Xie F, Kwan JSH, Chan WN, Fang C, Zhang J, Cheung AHK, Chow C, Leung GWM, Leung KT, Shi S, Zhang B, Wang S, Xu D, Fu K, Wong CC, Wu WKK, Chan MWY, Tang PMK, Tsang CM, Lo KW, Tse GMK, Yu J, To KF, Kang W. Chen B, et al. Clin Transl Med. 2023 Nov;13(11):e1481. doi: 10.1002/ctm2.1481. Clin Transl Med. 2023. PMID: 37983931 Free PMC article.
PIEZO1 expression was positively correlated with the YAP1 signature (CTGF, CYR61, and c-Myc, etc.) in primary samples. ...H. pylori-NF-kappaB activates the PIEZO1-YAP1-CTGF axis to remodel the GC microenvironment by promoting CAF infiltration. ...
PIEZO1 expression was positively correlated with the YAP1 signature (CTGF, CYR61, and c-Myc, etc.) in primary samples. ...H. pylori-N …
YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition.
Ajani JA, Xu Y, Huo L, Wang R, Li Y, Wang Y, Pizzi MP, Scott A, Harada K, Ma L, Yao X, Jin J, Zhao W, Dong X, Badgwell BD, Shanbhag N, Tatlonghari G, Estrella JS, Roy-Chowdhuri S, Kobayashi M, Vykoukal JV, Hanash SM, Calin GA, Peng G, Lee JS, Johnson RL, Wang Z, Wang L, Song S. Ajani JA, et al. Gut. 2021 Jan;70(1):55-66. doi: 10.1136/gutjnl-2019-319748. Epub 2020 Apr 27. Gut. 2021. PMID: 32345613 Free PMC article.
Immunofluorescence and immunohistochemical staining, RNA sequencing (RNA-Seq) and single-cell RNA-Seq (sc-RNA-Seq) were used to elucidate the expression of YAP1 and PC cell heterogeneity. LentiCRISPR/Cas9 knockout of YAP1 and a YAP1 inhibitor were used to dis …
Immunofluorescence and immunohistochemical staining, RNA sequencing (RNA-Seq) and single-cell RNA-Seq (sc-RNA-Seq) were used to elucidate th …
Propofol Inhibits Proliferation and Invasion of Stomach Cancer Cells by Regulating miR-205/YAP1 Axis.
Xian XS, Wang YT, Jiang XM. Xian XS, et al. Cancer Manag Res. 2020 Oct 29;12:10771-10779. doi: 10.2147/CMAR.S270344. eCollection 2020. Cancer Manag Res. 2020. PMID: 33149682 Free PMC article.
The dual-luciferase reporter assay revealed that YAP1 could be targeted and regulated by miR-205, and the rescue assay revealed that inhibiting miR-205 or overexpressing YAP1 could weaken the effect of propofol on the biological behaviors of SC cells. CONCLUSION: Pr …
The dual-luciferase reporter assay revealed that YAP1 could be targeted and regulated by miR-205, and the rescue assay revealed that …
AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis.
Zhou Y, Zhang J, Li H, Huang T, Wong CC, Wu F, Wu M, Weng N, Liu L, Cheng ASL, Yu J, Wong N, Lo KW, Tang PMK, Kang W, To KF. Zhou Y, et al. Oncogene. 2020 May;39(22):4375-4389. doi: 10.1038/s41388-020-1293-5. Epub 2020 Apr 20. Oncogene. 2020. PMID: 32313226 Free PMC article.
Hippo signaling functions to limit cellular growth, but the aberrant nuclear accumulation of its downstream YAP1 leads to carcinogenesis. YAP1/TEAD complex activates the oncogenic downstream transcription, such as CTGF and c-Myc. How YAP1 is protected in the …
Hippo signaling functions to limit cellular growth, but the aberrant nuclear accumulation of its downstream YAP1 leads to carcinogene …
Mechanotransduction and Cytoskeleton Remodeling Shaping YAP1 in Gastric Tumorigenesis.
Zhang J, Zhou Y, Tang PMK, Cheng ASL, Yu J, To KF, Kang W. Zhang J, et al. Int J Mol Sci. 2019 Mar 29;20(7):1576. doi: 10.3390/ijms20071576. Int J Mol Sci. 2019. PMID: 30934860 Free PMC article. Review.
In gastric cancer (GC), YAP1/TAZ functions as an oncogene and transcriptionally promotes tumor formation by cooperating with TEAD transcription factors. Apart from the classic role of Hippo-YAP1 cascade, in this review, we summarize the current investigations to hig …
In gastric cancer (GC), YAP1/TAZ functions as an oncogene and transcriptionally promotes tumor formation by cooperating with TEAD tra …
Helicobacter pylori-induced aberrant demethylation and expression of GNB4 promotes gastric carcinogenesis via the Hippo-YAP1 pathway.
Liu D, Liu Y, Zhu W, Lu Y, Zhu J, Ma X, Xing Y, Yuan M, Ning B, Wang Y, Jia Y. Liu D, et al. BMC Med. 2023 Apr 5;21(1):134. doi: 10.1186/s12916-023-02842-6. BMC Med. 2023. PMID: 37016382 Free PMC article.
Methylation-specific PCR, pyrosequencing, and mass spectrometry analysis were used to detect changes in methylation levels. GNB4, TET1, and YAP1 were overexpressed or knocked down in GC cell lines. We performed gain- and loss-of-function experiments, including CCK-8, EdU, …
Methylation-specific PCR, pyrosequencing, and mass spectrometry analysis were used to detect changes in methylation levels. GNB4, TET1, and …
LIX1 regulates YAP1 activity and controls the proliferation and differentiation of stomach mesenchymal progenitors.
McKey J, Martire D, de Santa Barbara P, Faure S. McKey J, et al. BMC Biol. 2016 Apr 28;14:34. doi: 10.1186/s12915-016-0257-2. BMC Biol. 2016. PMID: 27125505 Free PMC article.
We show that LIX1 is required for stomach SMC determination to regulate the expression of the pro-proliferative gene YAP1 and mesenchymal cell proliferation. However, as stomach development proceeds, sustained LIX1 expression has a negative impact on further …
We show that LIX1 is required for stomach SMC determination to regulate the expression of the pro-proliferative gene YAP1 and …
Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.
Hayakawa Y, Sakitani K, Konishi M, Asfaha S, Niikura R, Tomita H, Renz BW, Tailor Y, Macchini M, Middelhoff M, Jiang Z, Tanaka T, Dubeykovskaya ZA, Kim W, Chen X, Urbanska AM, Nagar K, Westphalen CB, Quante M, Lin CS, Gershon MD, Hara A, Zhao CM, Chen D, Worthley DL, Koike K, Wang TC. Hayakawa Y, et al. Cancer Cell. 2017 Jan 9;31(1):21-34. doi: 10.1016/j.ccell.2016.11.005. Epub 2016 Dec 15. Cancer Cell. 2017. PMID: 27989802 Free PMC article.
USP49 mediates tumor progression and poor prognosis through a YAP1-dependent feedback loop in gastric cancer.
Liu Z, Li J, Ding Y, Ma M, Chen J, Lei W, Li L, Yao Y, Yu X, Zhong M, Liao Q, Fang W, Fan L, Huang C, Zhong H, Wen Q, Fang Z, Chen J, Huang S, Xiong J, Xiang X, Deng J. Liu Z, et al. Oncogene. 2022 Apr;41(18):2555-2570. doi: 10.1038/s41388-022-02267-0. Epub 2022 Mar 22. Oncogene. 2022. PMID: 35318441
The importance of the Hippo-Yes-associated protein 1 (YAP1) pathway in gastric carcinogenesis and metastasis has attracted considerable research attention; however, the regulatory network of YAP1 in gastric cancer (GC) is not completely understood. ...Overexpression …
The importance of the Hippo-Yes-associated protein 1 (YAP1) pathway in gastric carcinogenesis and metastasis has attracted considerab …
113 results